t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma
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چکیده
منابع مشابه
BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma.
Follicular lymphoma (FL) is characterized by a relatively indolent clinical course, but the disease often transforms into a more aggressive large cell lymphoma with a rapidly progressive clinical course. In the present study, we analyzed 41 cases of FL known to have subsequently transformed to aggressive lymphoma and an additional 64 FL samples from patients not subsequently transformed. We stu...
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The article entitled “Renal Infiltration of Follicular Lymphoma”, written by Petkovic et al. and published in one of the recent issues of your journal, was quite interesting [1]. Here we would like to emphasize some relevant points. Extranodal disease is relatively common; any organ may be involved. The most common sites of extranodal disease include the bone marrow, skin, gastrointestinal trac...
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The fact that follicular lymphoma is characterized by a specific immune phenotype and a nonrandom chromosomal translocation which may be detected at the molecular level makes it possible to design novel therapeutic strategies for curative therapy. Molecular markers may be used to test hypotheses. Some current causes for optimism are reviewed.
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Follicular lymphoma (FL) is presented as a germinal centre B cell lymphoma that is characterized by an indolent clinical course, but remains - paradoxically - largely incurable to date. The last years have seen significant progress in our understanding of FL lymphomagenesis, which is a multi-step process beginning in the bone marrow with the hallmark t(14;18)(q32;q21) translocation. The pathobi...
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moderate nuclear sclerotic cataract in the right eye, and a well-centered posterior chamber intraocular lens in the left eye. No hypopyon was noted. There was a moderate vitreous haze in both eyes with a small area of retinitis along the superior temporal arcade of the left eye. Otherwise, the optic nerve, macula, and periphery were grossly normal in each eye. Given the clinical setting, a diag...
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ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2014
ISSN: 0732-183X,1527-7755
DOI: 10.1200/jco.2013.52.8190